Description

β-Endorphin, Trp(27)-2-Nitrophenylsulfenyl Chloride is a chemically modified derivative of the endogenous opioid peptide β-endorphin, specifically modified at the tryptophan residue with a 2-nitrophenylsulfenyl (NPS) protecting group. This derivative is a critical intermediate in peptide synthesis, enabling selective protection and deprotection strategies essential for constructing complex peptide structures. It is primarily utilized by research institutions and pharmaceutical developers engaged in advanced neuropeptide research, opioid receptor studies, and the synthesis of novel peptide-based therapeutics.

Application

• Peptide Synthesis Intermediate: Serves as a key building block in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled assembly of β-endorphin analogs.
• Neuroscience Research: Used in the study of opioid receptor binding, signal transduction pathways, and the structure-activity relationships (SAR) of endorphins.
• Pharmaceutical Development: Employed in the research and development of novel analgesic and neuroprotective peptide drugs.
• Bioconjugation & Labeling: The reactive NPS-chloride group allows for specific modifications, facilitating the creation of labeled peptides for imaging or diagnostic assays.
• Protecting Group Chemistry: Acts as a reagent for the selective protection of tryptophan residues in complex peptide and protein engineering projects.

Basic Information

Product Name	β-Endorphin, Trp(27)-2-Nitrophenylsulfenyl Chloride
CAS No.	82114-14-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	β-Endorphin Trp(27)-NPS-Chloride; NPS-β-Endorphin; 2-Nitrophenylsulfenyl Chloride derivative of β-Endorphin; β-Endorphin [Trp27(NPS)]; Opioid Peptide Derivative; NPS-Protected β-Endorphin; CAS 82114-14-5
EINECS	Contact for details

Quality Control

Our β-Endorphin, Trp(27)-2-Nitrophenylsulfenyl Chloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and potency. Allow the product to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.