Description

2-Chloro-4-Trifluoromethylbenzaldehyde is a versatile aromatic aldehyde building block characterized by its chloro and trifluoromethyl substituents, which confer unique electronic and steric properties. This compound is essential for the synthesis of advanced intermediates in pharmaceutical and agrochemical research, where its reactive aldehyde group enables the construction of complex molecular architectures. It is primarily sought after by R&D chemists and process development teams in the fine chemical, pharmaceutical, and crop protection industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of molecules with fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group is a critical pharmacophore for activity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and functional groups.
• Dye and Pigment Intermediate: Acts as a starting material for the manufacture of specialized dyes and pigments.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for creating biaryl structures.

Basic Information

Product Name	2-Chloro-4-Trifluoromethylbenzaldehyde
CAS No.	82096-91-1
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-tolualdehyde; 2-Chloro-α,α,α-trifluoro-4-methylbenzaldehyde; 4-(Trifluoromethyl)-2-chlorobenzaldehyde; 2-Chloro-4-(trifluoromethyl)benzaldehyde; Benzaldehyde, 2-chloro-4-(trifluoromethyl)-; 2-Chloro-α,α,α-trifluoro-p-tolualdehyde; 2-Chloro-4-trifluoromethylbenzaldehyde
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Trifluoromethylbenzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flame. For long-term storage, consider packaging under an inert atmosphere such as nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.