Description

(S)-Tofisopam is the single enantiomer of the racemic anxiolytic agent tofisopam, representing a high-purity chiral building block of significant interest in advanced pharmaceutical research and development. Its value lies in enabling the study of stereospecific biological activity and the potential development of more targeted and efficacious therapeutics. This compound is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel psychotropic agents and chiral drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of enantiomerically pure anxiolytic and psychotropic drugs.
• Active Pharmaceutical Ingredient (API) Research: Used in preclinical studies to investigate the pharmacological profile, metabolism, and receptor binding affinity of the (S)-enantiomer.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in chiral separation techniques like HPLC and SFC.
• Medicinal Chemistry: A crucial building block for synthesizing novel analogs and derivatives to explore structure-activity relationships (SAR).
• Biochemical Research: Tool compound for studying GABAergic systems and other neurological pathways implicated in anxiety disorders.

Basic Information

Product Name	(S)-Tofisopam
CAS No.	82059-51-6
Molecular Formula	C22H26N2O4
Molecular Weight	382.46 g/mol
Synonyms	(S)-Tofisopam; (S)-1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine; (S)-Emandaxin; (S)-Grandaxin; (S)-Tofizopam; Dextrotofisopam; (S)-Enantiomer of Tofisopam
EINECS	Contact for details

Quality Control

Our (S)-Tofisopam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material is suitable for demanding research applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.