Description

Dextofisopam, (R)-(5R)-1-(3,4-Dimethoxyphenyl)-5-Ethyl-7,8-Dimethoxy-4-Methyl-5H-2,3-Benzodiazepine is a high-purity, chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key intermediate or reference standard for investigating novel therapeutic agents, particularly those targeting the central nervous system. It is needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of novel benzodiazepine-based drug candidates.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Employed in preclinical studies to investigate structure-activity relationships (SAR) and receptor binding profiles.
• Process Chemistry Development: Utilized for optimizing synthetic routes, scaling up production, and developing robust manufacturing processes.
• Metabolite Synthesis: Acts as a precursor for the synthesis of potential drug metabolites for pharmacokinetic and toxicological studies.

Basic Information

Product Name	Dextofisopam
CAS No.	82059-50-5
Molecular Formula	C22H28N2O4
Molecular Weight	384.47 g/mol
Synonyms	(R)-Dextofisopam; (5R)-Dextofisopam; (R)-(5R)-1-(3,4-Dimethoxyphenyl)-5-ethyl-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine; Dextofisopam (enantiomer); 82059-50-5; Tocris-2682; 5H-2,3-Benzodiazepine derivative
EINECS	Contact for details

Quality Control

Our Dextofisopam is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development purposes. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.