Description

Angiotensinogen (1-13) (Human) is a specific peptide fragment derived from the N-terminal sequence of human angiotensinogen, the precursor to the potent vasoconstrictor angiotensin II. This high-purity reference standard is critical for biochemical research, enabling precise study of the renin-angiotensin system (RAS) and its role in cardiovascular regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers focused on hypertension, heart failure, and related metabolic disorders. Consistent quality and reliable supply are paramount for ensuring reproducible experimental and assay results.

Application

• Biochemical Research Standard: Used as a high-purity reference compound in studies of the renin-angiotensin-aldosterone system (RAAS) pathway.
• Enzyme Kinetics & Assay Development: Serves as a specific substrate for renin activity assays and kinetic studies to screen for renin inhibitors.
• Pharmaceutical R&D: A key intermediate in the development and validation of novel therapeutics targeting hypertension and cardiovascular diseases.
• Diagnostic Reagent Manufacturing: Employed in the production of calibrators and controls for clinical diagnostic kits measuring renin activity or angiotensinogen levels.
• Metabolic Disorder Studies: Facilitates research into the role of angiotensinogen fragments in conditions like diabetes and preeclampsia.
• Cell Signaling & Receptor Studies: Used to investigate peptide-receptor interactions and downstream signaling cascades in vascular and renal tissues.

Basic Information

Product Name	Angiotensinogen (1-13) (Human)
CAS No.	82048-97-3
Molecular Formula	C68H105N19O19S
Molecular Weight	1524.8 g/mol
Synonyms	Human Angiotensinogen (1-13); Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His; DRVYIHPFHLVIH; Angiotensinogen Fragment 1-13; Angiotensin I Precursor (1-13); AGT (1-13); Renin Substrate Tetradecapeptide (1-13)
EINECS	Contact for details

Quality Control

Every batch of Angiotensinogen (1-13) (Human) is manufactured and tested under stringent quality management systems. Our products undergo rigorous analytical testing, including HPLC, MS, and amino acid analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and impurity profiles is provided with each shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.