Description

Hemoglobin Miyashiro is a specific, naturally occurring variant of hemoglobin, a critical oxygen-transporting metalloprotein found in red blood cells. This compound is of significant interest in biochemical research and diagnostic development due to its unique structural and functional properties. It is primarily utilized by researchers and manufacturers in the fields of clinical diagnostics, hematology research, and the development of reference standards for blood analysis.

Application

• Clinical Diagnostic Reagents: Used as a key component or calibrator in assays for hemoglobin analysis and blood gas testing.
• Biochemical Research: Serves as a model protein for studying oxygen binding kinetics, protein stability, and heme-protein interactions.
• Reference Standard Material: Employed in the calibration and validation of laboratory equipment, such as hematology analyzers and spectrophotometers.
• Hematology Studies: Facilitates research into hemoglobinopathies, thalassemias, and other blood-related disorders.
• Pharmaceutical Development: Investigated for potential applications in oxygen therapeutics and blood substitutes.
• Educational Purposes: Used in academic settings for teaching advanced concepts in protein chemistry and physiology.

Basic Information

Product Name	Hemoglobin Miyashiro
CAS No.	82030-01-1
Molecular Formula	C2952H4664N812O832S8Fe4
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Hb Miyashiro; Hemoglobin Variant Miyashiro; Miyashiro Hemoglobin; HBB:c.364G>C (p.Glu122Gln); Hemoglobin D-Ibadan; Unstable Hemoglobin Miyashiro; Oxyhemoglobin Miyashiro; Deoxyhemoglobin Miyashiro
EINECS	Contact for details

Quality Control

Our Hemoglobin Miyashiro is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and stability. We adhere to relevant guidelines for the preparation of biological and biochemical reagents to support reliable and reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Avoid repeated freeze-thaw cycles. Due to its nature as an easily oxidized (store under inert atmosphere) and light-sensitive protein, handling should minimize exposure to air and strong light. The product should be kept in a controlled environment away from moisture and contaminants.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Conforms to characteristic spectrum
Purity (HPLC)	≥ 95% (Hemoglobin Miyashiro)
Protein Content (Biuret)	≥ 90%
Methemoglobin Content	≤ 5%
Solubility	Clear solution in buffer
pH (in solution)	6.5 - 7.5
Endotoxin	< 1.0 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.