Description

Hemoglobin F Kotobuki is a highly purified, standardized preparation of fetal hemoglobin (HbF), a key protein in oxygen transport. This product is essential for research, diagnostic, and calibration applications requiring a consistent and reliable source of authentic HbF. It is primarily utilized by biotechnology firms, clinical diagnostic laboratories, and academic research institutions focused on hematology, hemoglobinopathies, and blood substitute development.

Application

• Diagnostic Calibration & Control: Serves as a critical standard and control material in clinical analyzers for the accurate quantification of HbF levels, essential for diagnosing and monitoring conditions like β-thalassemia and sickle cell disease.
• Biomedical Research: Used as a fundamental reagent in studies investigating the structure, function, and oxygen-binding kinetics of fetal hemoglobin, as well as in research on hemoglobin switching and related genetic disorders.
• Assay Development & Validation: Acts as a reference standard in the development and validation of immunoassays (ELISA), chromatography (HPLC), and electrophoresis methods specific to HbF detection.
• Quality Control in Pharmaceutical Manufacturing: Employed as a process control standard in the production and quality testing of biopharmaceuticals derived from or targeting hemoglobin pathways.
• Educational & Training Purposes: Provides a high-quality specimen for teaching and training in clinical laboratory science, biochemistry, and molecular biology programs.

Basic Information

Product Name	Hemoglobin F Kotobuki
CAS No.	82029-98-9
Molecular Formula	Contact for details
Molecular Weight	~64,500 Da (for tetramer)
Synonyms	Fetal Hemoglobin
Hb F
Hemoglobin F
α2γ2 Hemoglobin
Foetal Haemoglobin
Kotobuki Hemoglobin F
Human Fetal Hemoglobin
EINECS	Contact for details

Quality Control

Our Hemoglobin F Kotobuki is produced and tested under a rigorous quality management system. Each lot is characterized for identity, purity, and functional activity to ensure it meets the exacting standards required for critical research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), spectral properties, and functional assays is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C. Avoid repeated freeze-thaw cycles. Handle according to good laboratory practices for biological materials.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (UV-Vis)	Conforms to characteristic spectrum of Oxy-HbF
Purity (HPLC)	≥ 95% (HbF)
Hemoglobin A2 (HPLC)	≤ 2.0%
Methemoglobin	≤ 3.0%
Protein Content	Specified on COA
Solubility	Clear solution in appropriate buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.