Description

2,4(1H,3H)-Pyrimidinedione, 3-(1,3-Dihydro-3-Oxo-1-Isobenzofuranyl)-5- Fluoro- is a high-purity fluorinated pyrimidinedione derivative, a crucial advanced pharmaceutical intermediate. Its value lies in its role as a key building block for the synthesis of novel, potent active pharmaceutical ingredients (APIs), particularly in antiviral and anticancer research. This compound is essential for R&D laboratories and manufacturers in the pharmaceutical and fine chemical sectors seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel antiviral and anticancer drug candidates.
• Antiviral Drug Research: Key precursor in the development of nucleoside/nucleotide analog prodrugs targeting viral polymerases.
• Oncology Research: Used in medicinal chemistry for creating targeted therapies that interfere with DNA synthesis and cell proliferation.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and mechanism-of-action investigations.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce complex heterocyclic structures with specific biological activity.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione, 3-(1,3-Dihydro-3-Oxo-1-Isobenzofuranyl)-5- Fluoro-
CAS No.	82023-29-8
Molecular Formula	C₁₂H₇FN₂O₄
Molecular Weight	262.20 g/mol
Synonyms	5-Fluoro-3-(1,3-dihydro-3-oxo-1-isobenzofuranyl)-2,4(1H,3H)-pyrimidinedione; 3-(1,3-Dihydro-3-oxo-1-isobenzofuranyl)-5-fluorouracil; 5-Fluoro-3-(3-oxophthalanyl)uracil; 5-Fluoro-3-(phthal-3-on-1-yl)uracil; 82023-29-8; Fluorinated phthalanyl uracil derivative; 1-Isobenzofuran-1(3H)-one, 3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-3-yl)-
EINECS	Contact for details

Quality Control

Our 2,4(1H,3H)-Pyrimidinedione, 3-(1,3-Dihydro-3-Oxo-1-Isobenzofuranyl)-5- Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.