Description

Fmoc-Leu-Gly-Oh CAS NO 82007-05-4 is a high-purity, protected dipeptide building block essential for solid-phase peptide synthesis (SPPS). This compound provides critical control over the sequential assembly of peptides, enabling the production of complex and high-value biomolecules. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in peptide-based drug discovery, API development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid derivative for the automated or manual synthesis of custom peptides.
• Pharmaceutical Intermediates: Serves as a key intermediate in the research and development of therapeutic peptides and peptidomimetics.
• Bioconjugation & Probe Development: Used to incorporate the Leu-Gly sequence into larger constructs for biological studies, diagnostics, or targeted delivery systems.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Industrial Research: A standard reagent for studying peptide structure-activity relationships (SAR), enzyme substrates, and receptor ligands.
• Process Development & Scale-up: Supports the transition from milligram-scale research to gram and kilogram-scale production for clinical and commercial supplies.

Basic Information

Product Name	Fmoc-Leu-Gly-Oh
CAS No.	82007-05-4
Molecular Formula	C23H26N2O5
Molecular Weight	410.46 g/mol
Synonyms	Fmoc-Leu-Gly-OH; Fmoc-L-leucylglycine; N-(9-Fluorenylmethoxycarbonyl)-L-leucylglycine; (9H-Fluoren-9-yl)methyl (2S)-2-[[2-(2-aminoacetamido)-4-methylpentanoyl]amino]acetate; Fmoc-L-Leu-Gly-OH; N-α-Fmoc-L-leucylglycine; FMOC-Leu-Gly; Fmoc-Leu-Gly
EINECS	Contact for details

Quality Control

Our Fmoc-Leu-Gly-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.