Description

Cystatin CAS NO 81989-95-9 is a low molecular weight protein and a potent, reversible inhibitor of cysteine proteases. This compound is critical for regulating proteolytic activity in biological systems, ensuring precise control over protein degradation and turnover processes. It is an essential reagent for researchers and manufacturers in the life sciences, pharmaceutical development, and diagnostic industries, where it is used to study protease-related pathways and develop therapeutic and analytical applications.

Application

• Biomedical Research: Used as a standard and inhibitor in studies of cysteine protease enzymes like cathepsins, involved in cancer, neurodegenerative diseases, and osteoporosis.
• Diagnostic Kit Manufacturing: Serves as a key component in immunoassay kits for the detection and quantification of cystatin C, a biomarker for kidney function (glomerular filtration rate).
• Pharmaceutical Development: Employed in drug discovery programs targeting cysteine proteases for conditions such as parasitic infections, rheumatoid arthritis, and muscular dystrophy.
• Enzyme Activity Studies: Acts as a specific control inhibitor to measure the activity of papain, ficin, and other plant-derived or mammalian cysteine proteases in vitro.
• Cell Culture & Biochemistry: Utilized to modulate protease activity in cell lysates and tissue extracts to prevent unwanted protein degradation during experimental procedures.

Basic Information

Product Name	Cystatin
CAS No.	81989-95-9
Molecular Formula	Contact for details
Molecular Weight	~13 kDa (Approx.)
Synonyms	Cystatin C; Human Cystatin C; Cystatin 3; Post-γ-Globulin; Neuroendocrine Basic Polypeptide; γ-Trace Protein; CST3; ARMD11; Cysteine Protease Inhibitor 3
EINECS	Contact for details

Quality Control

Our Cystatin is produced and tested under strict quality management systems. Each batch undergoes rigorous analytical testing, including purity assessment by HPLC and functional activity assays, to ensure it meets the high standards required for research and in vitro diagnostic (IVD) use. Certificates of Analysis (COA) detailing purity, biological activity, and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, aliquots may be stored at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Biological Activity	≥ 90% of reference standard
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.