Description

(E)-9-Fluoro-11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo(B,E)Thiepin Hydrogen Maleate is a high-purity, non-racemic pharmaceutical intermediate and active ingredient of significant commercial interest. This compound is valued for its precise stereochemistry and functional groups, which are critical for advanced synthesis and research applications. It is primarily sought by pharmaceutical R&D teams, fine chemical manufacturers, and academic institutions engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs).
• Neurological & Psychiatric Research: Used in the development and study of compounds targeting central nervous system (CNS) receptors.
• Preclinical & Clinical Development: Serves as a reference standard or starting material for drug candidates in various stages of development.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial production of specialty pharmaceuticals.
• Academic & Contract Research: Utilized in medicinal chemistry programs and pharmacological studies within universities and CROs.
• Analytical Standard: Acts as a high-purity certified reference material (CRM) for quality control and method validation.

Basic Information

Product Name	(E)-9-Fluoro-11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo(B,E)Thiepin Hydrogen Maleate
CAS No.	81890-59-7
Molecular Formula	C23H24FNO4S
Molecular Weight	429.50 g/mol
Synonyms	Zuclopenthixol Acetate Impurity C; (E)-Zuclopenthixol Acetate Related Compound C; (Z)-9-Fluoro-11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo[B,E]Thiepin Maleate; (E)-Zuclopenthixol Acetate; cis-Zuclopenthixol Acetate; Zuclopenthixol Acetate E-Isomer; 81890-59-7; Zuclopenthixol Acetate EP Impurity C
EINECS	Contact for details

Quality Control

Our (E)-9-Fluoro-11-(3-Dimethylaminopropylidene)-6,11-Dihydrodibenzo(B,E)Thiepin Hydrogen Maleate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC and NMR, to ensure identity, purity, and stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific pharmacopeial (e.g., EP, USP) or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and opened in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (Anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (E-Isomer)
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.