Description

Elastin Polypentapeptide is a bioactive peptide sequence derived from the core structural motif of tropoelastin, the soluble precursor to elastin. This compound is valued for its ability to mimic the biological and physicochemical properties of native elastin, offering significant potential in advanced biomaterial and cosmetic applications. It is primarily sought by researchers and formulators in the pharmaceutical, biomedical engineering, and high-performance skincare industries for developing tissue scaffolds, drug delivery systems, and anti-aging formulations.

Application

• Biomedical Research & Tissue Engineering: As a key component in the development of synthetic elastin-like polymers (ELPs) and hydrogels for creating vascular grafts, skin substitutes, and other elastic tissue scaffolds.
• Cosmeceutical & Skincare Formulations: Incorporated into serums, creams, and masks for its purported skin-firming, moisturizing, and wrinkle-smoothing properties by promoting elastin synthesis and improving skin elasticity.
• Drug Delivery Systems: Utilized to create stimuli-responsive (e.g., temperature-sensitive) carriers for controlled release of therapeutic agents, leveraging its reversible phase transition behavior.
• Bioactive Coatings: Applied to medical devices and implants to enhance biocompatibility, reduce fibrosis, and promote better integration with host tissues.
• Advanced Material Science: Serves as a model compound for studying protein folding, self-assembly mechanisms, and the design of novel smart biomaterials.

Basic Information

Product Name	Elastin Polypentapeptide
CAS No.	81857-53-6
Molecular Formula	Typically (Val-Pro-Gly-Val-Gly)n
Molecular Weight	Variable, depending on the number of pentapeptide repeats (n). Contact for details on specific molecular weight.
Synonyms	Elastin Pentapeptide; Poly(VPGVG); (Val-Pro-Gly-Val-Gly)n; Elastin-like Polypeptide (ELP); Elastin Mimetic Peptide; VPGVG Polymer; Tropoelastin-derived Peptide; Bioelastin
EINECS	Contact for details

Quality Control

Our Elastin Polypentapeptide is produced under stringent conditions to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity assessment, amino acid analysis (AAA), and mass spectrometry (MS) for sequence confirmation. Certificates of Analysis (COA) detailing specific results for identity, purity, and residual solvents are provided with each shipment. We adhere to cGMP guidelines where applicable to support research and development requiring reliable, high-quality bioactive peptides.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For extended storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.