Description

Enkephalin, Dehydro-Ala(3)- CAS NO 81851-82-3 is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, characterized by the introduction of a dehydroalanine residue at position 3. This structural modification is crucial for enhancing metabolic stability and receptor selectivity, making it a valuable tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and opioid receptor studies.

Application

• Neuroscience Research: As a key reference standard and probe for studying delta (δ) and mu (μ) opioid receptor binding, activation, and signaling pathways.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the design of novel, non-addictive analgesic agents with improved stability profiles.
• Biochemical Assays: Used in competitive binding assays, enzyme inhibition studies, and functional cellular assays to evaluate peptide-receptor interactions.
• Metabolic Stability Studies: Employed as a model compound to investigate the effects of structural modifications (like dehydroamino acids) on peptide degradation and half-life.
• Academic & Clinical Research: Fundamental tool for exploring the physiological and pathological roles of the enkephalinergic system in pain, mood, and addiction.

Basic Information

Product Name	Enkephalin, Dehydro-Ala(3)-
CAS No.	81851-82-3
Molecular Formula	C27H35N5O7
Molecular Weight	541.60 g/mol
Synonyms	Dehydroalanine(3)-Enkephalin; [δAla3]-Enkephalin; H-Tyr-Gly-δAla-Phe-Leu-OH; H-Tyr-Gly-(Z)-Dehydroalanine-Phe-Leu-OH; (Z)-Dehydroalanine3-Enkephalin; δ-Alanine(3)-Enkephalin; Opioid Peptide Analog
EINECS	Contact for details

Quality Control

Our Enkephalin, Dehydro-Ala(3)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.