Description

Vesnarinone is a synthetic, small-molecule compound belonging to the class of phosphodiesterase III (PDE III) inhibitors. This compound is of significant interest in pharmaceutical research and development due to its unique inotropic and vasodilatory properties. It is primarily utilized by pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in cardiovascular drug discovery and development.

Application

• Pharmaceutical Active Ingredient (API) Development: Serves as a key intermediate or the active pharmaceutical ingredient in the research and formulation of novel cardiovascular therapeutics.
• Cardiovascular Research: Used as a reference standard or experimental compound in biochemical and pharmacological studies targeting heart failure, myocardial contractility, and vascular tone regulation.
• Mechanism of Action Studies: Employed in vitro and in vivo to investigate the effects of selective PDE III inhibition on cyclic adenosine monophosphate (cAMP) levels and cardiac function.
• Reference Standard for Analytical Testing: Provides a high-purity benchmark for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Preclinical and Clinical Trial Material: Supplied under appropriate quality agreements for use in non-clinical safety studies and clinical trial material (CTM) manufacturing.

Basic Information

Product Name	Vesnarinone
CAS No.	81840-15-5
Molecular Formula	C₂₂H₂₅N₃O₄
Molecular Weight	395.45 g/mol
Synonyms	3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone; OPC-8212; Arkin-Z; 1,2,3,4-Tetrahydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-oxoquinoline; Vesnarinon; 6-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
EINECS	Contact for details

Quality Control

Our Vesnarinone is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for research and development purposes. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.