Description

Enkephalin-Met, Tyr-o-Sulfate is a chemically modified, sulfated derivative of the endogenous opioid peptide [Met]-enkephalin. This modification significantly alters its receptor binding profile and metabolic stability, making it a critical tool for advanced neuroscience and pharmacology research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers investigating neuropeptide signaling, pain pathways, and receptor-ligand interactions. Our supply ensures high-purity material essential for generating reliable and reproducible experimental data.

Application

• Neuroscience Research: As a key reference standard and probe for studying sulfated neuropeptide interactions with opioid and related receptors.
• Pharmacological Assay Development: Used in high-throughput screening (HTS) and binding assays to discover and characterize new analgesic compounds.
• Biochemical Standard: Serves as a critical calibrant and control in quantitative analytical methods such as LC-MS/MS for peptide quantification.
• Metabolic Pathway Studies: Investigates the role of tyrosine O-sulfation in peptide hormone activity, stability, and clearance.
• Diagnostic Reagent Manufacturing: Potential use as a component in specialized immunoassays or diagnostic kits targeting modified neuropeptides.
• Academic & Institutional Research: Fundamental research into the structure-activity relationships (SAR) of endogenous opioid peptides.

Basic Information

Product Name	Enkephalin-Met, Tyr-o-Sulfate
CAS No.	81788-49-0
Molecular Formula	C28H37N5O10S
Molecular Weight	635.69 g/mol
Synonyms	[Met5]-Enkephalin, Tyr-O-sulfate; H-Tyr(SO3H)-Gly-Gly-Phe-Met-OH; Methionine Enkephalin, O-Sulfotyrosine; Tyr-Sulfate-Met-Enkephalin; Opioid Peptide [Met]enkephalin Sulfate; Y(SO3H)GGPM; L-Tyrosine, O-sulfo-, pentapeptide with glycylglycyl-L-phenylalanyl-L-methionine; 81788-49-0
EINECS	Contact for details

Quality Control

Every batch of Enkephalin-Met, Tyr-o-Sulfate is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to support your research integrity, including purity verification by HPLC, mass spectrometry (MS) for identity confirmation, and detailed impurity profiling. A Certificate of Analysis (COA) documenting batch-specific results is supplied with each order to ensure traceability and compliance with your quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in water, dimethyl sulfoxide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.