Description

1-n-Boc-3-Fluoro-Aniline is a high-purity, protected aniline derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the orthogonal protection of the amine group and the strategic introduction of a fluorine atom, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated drug candidates, including kinase inhibitors, receptor antagonists, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where the fluorine atom enhances biological activity and metabolic stability.
• Peptide Chemistry & Linker Development: Serves as a protected aniline precursor for constructing fluorinated amino acid analogs or for incorporation into specialized chemical linkers and spacers.
• Material Science Research: Employed in the synthesis of fluorinated aromatic polymers, liquid crystals, or organic electronic materials to modify physical properties.
• Fluorine-Containing Scaffold Library: A versatile starting material for combinatorial and parallel synthesis to create diverse chemical libraries for high-throughput screening.

Basic Information

Product Name	1-n-Boc-3-Fluoro-Aniline
CAS No.	81740-18-3
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	3-Fluoro-N-(tert-butoxycarbonyl)aniline; tert-Butyl (3-fluorophenyl)carbamate; 1-Boc-3-fluoroaniline; N-Boc-3-fluoroaniline; N-(tert-Butoxycarbonyl)-3-fluoroaniline; 3-Fluoroaniline, N-BOC-protected; 3-Fluoroaniline N-Boc derivative; 1-(tert-Butoxycarbonyl)-3-fluoroaniline
EINECS	Contact for details

Quality Control

Our 1-n-Boc-3-Fluoro-Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.