Description

(D-Ala2)-Leucine Enkephalin-Arg CAS NO 81733-79-1 is a synthetic peptide analog of the endogenous opioid peptide leucine enkephalin, modified with a D-alanine residue at position 2 and an arginine extension. This modification enhances its metabolic stability and receptor selectivity, making it a critical tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pain management, and opioid receptor studies.

Application

• Neuroscience Research: As a selective ligand for studying delta (δ) opioid receptor signaling pathways and function.
• Pharmacological Assay Development: Used as a reference standard or active agent in high-throughput screening (HTS) for novel analgesic drug discovery.
• Biochemical Studies: Investigation of peptide stability, blood-brain barrier penetration, and structure-activity relationships (SAR) of enkephalin analogs.
• Cell Signaling Research: Probing the role of opioid receptors in cellular processes such as pain modulation, reward, and addiction.
• Reference Standard: For quality control and analytical method development (e.g., HPLC, LC-MS) in peptide synthesis and characterization.

Basic Information

Product Name	(D-Ala2)-Leucine Enkephalin-Arg
CAS No.	81733-79-1
Molecular Formula	C34H48N8O8
Molecular Weight	696.80 g/mol
Synonyms	[D-Ala2]-Leu-Enkephalin-Arg; DADLE-Arg; (D-Ala2)-Leu-Enkephalin-Arg-OH; Tyr-D-Ala-Gly-Phe-Leu-Arg; H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH; Opioid Peptide Analog; Delta Opioid Receptor Agonist Analog; Leu-Enkephalin, [D-Ala2]-Arg-
EINECS	Contact for details

Quality Control

Our (D-Ala2)-Leucine Enkephalin-Arg is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.