Description

Leucine Enkephalin Acetate Salt is a synthetic pentapeptide and a stable acetate salt form of the endogenous opioid neuropeptide. This compound is a critical research tool for studying the opioid system, pain pathways, and neurological signaling. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, pharmacology, and drug discovery.

Application

• Neuroscience Research: Used as a standard and reference compound in studies of opioid receptor binding, activation, and signal transduction.
• Pharmacological Assays: Serves as a key agonist in in vitro and in vivo assays to investigate analgesic mechanisms and tolerance development.
• Biochemical Standard: Employed in HPLC and mass spectrometry as a calibration standard for peptide analysis and quantification.
• Drug Discovery: Acts as a lead compound or a molecular template for the design and screening of novel analgesic and neuroprotective agents.
• Cell Signaling Studies: Applied in research exploring the role of enkephalins in immune modulation, stress response, and behavioral models.

Basic Information

Product Name	Leucine Enkephalin Acetate Salt
CAS No.	81678-16-2
Molecular Formula	C34H48N6O10 • xC2H4O2
Molecular Weight	711.8 g/mol (Free base: 555.6 g/mol)
Synonyms	Leu-Enkephalin Acetate; [Leu5]-Enkephalin Acetate Salt; H-Tyr-Gly-Gly-Phe-Leu-OH acetate; YGGFL acetate; Opioid Peptide (Leu-Enkephalin) Acetate; L-Enkephalin Acetate; NSC 326231 Acetate
EINECS	Contact for details

Quality Control

Our Leucine Enkephalin Acetate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and acetates. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 70.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	5.0% - 12.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.