Description

Fmoc-Ser(Tbu)-Gly-Oh is a high-purity, protected dipeptide building block essential for solid-phase peptide synthesis (SPPS). This compound matters because it provides a precisely controlled sequence for constructing complex peptides and peptidomimetics, ensuring high coupling efficiency and minimal racemization. It is critically needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected dipeptide fragment for the automated or manual assembly of target peptide sequences.
• Pharmaceutical R&D: For the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Serving as a spacer or functional component in the synthesis of peptide-protein or peptide-small molecule conjugates.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify bioactive peptide leads.
• Academic Research: A fundamental reagent in university and institutional labs studying protein structure-function relationships and peptide chemistry.
• Production of Custom Peptides: Employed by CROs and CDMOs for the reliable and scalable synthesis of custom peptides for clients.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Gly-Oh
CAS No.	81672-17-5
Molecular Formula	C24H28N2O6
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-Ser(tBu)-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serylglycine; Fmoc-L-Serine(O-tert-butyl)-glycine; Fmoc-Ser(O-tBu)-Gly-OH; N-Fmoc-O-tert-butyl-L-serylglycine; Fmoc-Ser(t-Butyl)-Gly; Fmoc-Ser(Trt)-Gly-OH (common alternative protection); Fmoc-Ser(OtBu)-Gly
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Gly-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable to support our customers' regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.