Description

5-Bromopyrimidin-2(1H)-One Hydrobromide is a high-purity, halogenated pyrimidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its reactivity, particularly in cross-coupling reactions and as a precursor for more complex heterocyclic systems. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in kinase inhibitor and antiviral agent discovery.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and plant growth regulators that require a brominated pyrimidine core.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for metal-organic frameworks (MOFs), and specialty polymers.
• Chemical Biology & Proteomics: Acts as a versatile scaffold for designing molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Academic & Contract Research: Essential for methodological development in organic chemistry laboratories and for custom synthesis projects.

Basic Information

Product Name	5-Bromopyrimidin-2(1H)-One Hydrobromide
CAS No.	81590-30-9
Molecular Formula	C4H4BrN2O • HBr
Molecular Weight	279.90 g/mol
Synonyms	5-Bromo-2-hydroxypyrimidine hydrobromide; 5-Bromo-2-pyrimidinol hydrobromide; 5-Bromo-1H-pyrimidin-2-one hydrobromide; 2-Hydroxy-5-bromopyrimidine hydrobromide; 5-Bromopyrimidin-2-ol hydrobromide; 5-Bromo-2(1H)-pyrimidinone hydrobromide
EINECS	Contact for details

Quality Control

Our 5-Bromopyrimidin-2(1H)-One Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.