Description

2,3,3-Trimethyl-6-(Trifluoromethyl)-3H-Indole is a high-value, specialized indole derivative characterized by its unique trifluoromethyl-substituted aromatic structure. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the introduction of lipophilic and electron-withdrawing groups. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel molecules with targeted properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those requiring a trifluoromethylated indole scaffold for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Building block for developing new-generation pesticides and herbicides, where the CF3 group can improve lipophilicity and biological activity.
• Organic Light-Emitting Diode (OLED) Materials: Used in the research and production of electron-transporting or host materials for display and lighting technologies.
• Dye and Pigment Intermediate: Serves as a starting material for synthesizing specialized fluorinated dyes and functional pigments.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalytic processes.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorination on molecular properties.

Basic Information

Item	Detail
Product Name	2,3,3-Trimethyl-6-(Trifluoromethyl)-3H-Indole
CAS No.	81558-23-8
Molecular Formula	C12H12F3N
Molecular Weight	227.23 g/mol
Synonyms	6-(Trifluoromethyl)-2,3,3-trimethyl-3H-indole; 2,3,3-Trimethyl-6-trifluoromethylindole; 3H-Indole, 2,3,3-trimethyl-6-(trifluoromethyl)-; 6-Trifluoromethyl-2,3,3-trimethylindole; 81558-23-8; Trimethyl(trifluoromethyl)indole
EINECS	Contact for details

Quality Control

Our 2,3,3-Trimethyl-6-(Trifluoromethyl)-3H-Indole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat and incompatible materials. Due to its light-sensitive nature, containers should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.