Description

Substance P, Amino(4)-Phe(7)- is a specific, high-purity analog of the neuropeptide Substance P, a key signaling molecule in the nervous system. This modified peptide is critical for advanced research into neurokinin-1 (NK1) receptor interactions, pain pathways, and inflammatory responses. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, drug discovery, and peptide-based therapeutic development.

Application

• Neuroscience Research: As a potent and selective neurokinin-1 (NK1) receptor ligand for studying pain transmission, neuroinflammation, and central nervous system signaling.
• Drug Discovery & Development: Serving as a reference standard or a lead compound in the design of novel analgesics, anti-inflammatory agents, and anti-emetics targeting the NK1 receptor pathway.
• Biochemical Assays: Used in receptor binding studies, functional cell-based assays (e.g., calcium flux), and enzyme-linked immunosorbent assays (ELISAs) to quantify biological activity.
• Pharmacology Studies: Investigating the role of Substance P in conditions such as migraine, arthritis, depression, and nausea, facilitating mechanism-of-action research.
• Peptide Chemistry & Custom Synthesis: Acting as a building block or intermediate for the synthesis of more complex peptide analogs with tailored biological properties.

Basic Information

Product Name	Substance P, Amino(4)-Phe(7)-
CAS No.	81538-91-2
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.6 g/mol
Synonyms	[pGlu5, MePhe8, Sar9]-Substance P (5-11); Substance P (5-11), [pGlu5, N-MePhe8, Sar9]-; [pGlu5, N-MePhe8, Sar9]-Substance P(5-11); Amino(4)-Phe(7)-Substance P; NK1 Receptor Agonist Analog; Neurokinin-1 Receptor Ligand; SP analog
EINECS	Contact for details

Quality Control

Our Substance P, Amino(4)-Phe(7)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant standards for research-grade biochemicals, ensuring suitability for sensitive in vitro and in vivo applications.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.