Description

Nafamostat Mesylate CAS NO 81525-10-2 is a synthetic serine protease inhibitor with potent anticoagulant and anti-inflammatory properties. This high-purity compound is critical for research and development in life sciences and serves as a key active pharmaceutical ingredient (API) in therapeutic formulations. It is primarily utilized by pharmaceutical manufacturers, biotechnology research institutions, and clinical diagnostic developers.

Application

• Pharmaceutical API: Used as the active ingredient in anticoagulant and anti-inflammatory drug formulations.
• Biomedical Research: A vital tool compound for studying serine protease mechanisms, inflammation pathways, and coagulation cascades in vitro.
• Therapeutic Development: Investigated for potential applications in treating conditions like pancreatitis, disseminated intravascular coagulation (DIC), and as an anticoagulant in extracorporeal circulation.
• Diagnostic Reagent Component: Employed in the development of clinical diagnostic kits and assays that measure protease activity or require controlled anticoagulation.
• Cell Culture & Biochemistry: Used to inhibit specific proteases in experimental protocols to prevent unwanted protein degradation.

Basic Information

Product Name	Nafamostat Mesylate
CAS No.	81525-10-2
Molecular Formula	C19H17N5O2 • CH4O3S
Molecular Weight	347.37 g/mol (Free base: 259.27 g/mol)
Synonyms	6-Amidino-2-naphthyl 4-guanidinobenzoate dimethanesulfonate; FUT-175; Nafamostat; Futhan; 4-Guanidinobenzoic Acid 6-Amidino-2-naphthyl Ester Dimethanesulfonate; 6-Amidino-2-naphthyl 4-Guanidinobenzoate Dimethanesulfonate; Nafamostat Dimethanesulfonate
EINECS	Contact for details

Quality Control

Our Nafamostat Mesylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.