Description

6-Azidotryptophan is a non-canonical amino acid derivative featuring a reactive azido group at the 6-position of the indole ring. This compound is a critical building block in chemical biology and bioconjugation, enabling site-specific labeling of proteins via bioorthogonal click chemistry reactions such as the Staudinger-Bertozzi ligation or copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and advanced materials science for creating modified biologics, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation & Protein Labeling: Site-specific incorporation into proteins for subsequent click chemistry modification with fluorescent dyes, biotin, or other functional molecules.
• Antibody-Drug Conjugate (ADC) Development: Enables the precise attachment of cytotoxic payloads to antibodies via a stable triazole linkage.
• Chemical Biology Research: A key tool for studying protein structure, function, and interactions through bioorthogonal tagging strategies.
• Proteomics & Biomarker Discovery: Used to label and enrich specific proteins or peptides for mass spectrometry analysis.
• Material Science: Functionalization of surfaces and polymers with bioactive peptides or proteins.
• Diagnostic Reagent Synthesis: Production of labeled antigens or antibodies for immunoassays and imaging applications.

Basic Information

Product Name	6-Azidotryptophan
CAS No.	81524-70-1
Molecular Formula	C11H11N5O2
Molecular Weight	245.24 g/mol
Synonyms	6-Azido-L-tryptophan; (2S)-2-Amino-3-(6-azido-1H-indol-3-yl)propanoic acid; L-6-Azidotryptophan; 6-N3-Trp; AzTrp; 6-Azidoindole-3-alanine; Tryptophan, 6-azido-
EINECS	Contact for details

Quality Control

Our 6-Azidotryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to ensure reproducibility and reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enantiomeric Purity (Chiral HPLC)	≥ 98% ee (L-isomer)
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.