Description

Valyl-Leucyl-Arginine-4-Methoxy-2-Naphthylamide is a specialized fluorogenic peptide substrate designed for high-sensitivity enzymatic assays. This compound is critical for researchers and quality control laboratories requiring precise measurement of protease activity, particularly for enzymes like thrombin and trypsin. It is primarily utilized in the pharmaceutical, biotechnology, and diagnostic industries for biochemical research, drug discovery, and enzyme characterization.

Application

• Protease Activity Assays: As a fluorogenic substrate for the kinetic measurement of serine proteases, including thrombin, trypsin, and related enzymes.
• Biochemical Research: Used in enzyme kinetics studies, inhibitor screening, and mechanistic investigations in academic and industrial R&D settings.
• Diagnostic Development: A key component in the development of in vitro diagnostic kits for coagulation disorders and other protease-related conditions.
• Pharmaceutical Quality Control: Employed in potency testing and stability studies of biopharmaceuticals that involve protease activity.
• High-Throughput Screening (HTS): Ideal for automated screening platforms in drug discovery to identify novel protease inhibitors or activators.

Basic Information

Product Name	Valyl-Leucyl-Arginine-4-Methoxy-2-Naphthylamide
CAS No.	81523-92-4
Molecular Formula	C₃₃H₅₀N₈O₆
Molecular Weight	658.80 g/mol
Synonyms	Val-Leu-Arg-4-Methoxy-2-Naphthylamide; VLR-4M2NA; L-Valyl-L-leucyl-L-arginine 4-methoxy-2-naphthylamide; Fluorogenic Thrombin Substrate; Boc-Val-Leu-Arg-4-Methoxy-2-Naphthylamide (protected form); Protease Substrate 81523-92-4; Trypsin Fluorogenic Substrate; AMC-based peptide substrate analog.
EINECS	Contact for details

Quality Control

Our Valyl-Leucyl-Arginine-4-Methoxy-2-Naphthylamide is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.