Description

Acetyl-(D-Lys89,Sar90)-β-Lipotropin (88-91) (Human) is a synthetic peptide fragment derived from the human β-lipotropin hormone, specifically acetylated at the N-terminus and featuring D-Lysine and Sarcosine substitutions at positions 89 and 90. This compound is a critical research-grade biochemical tool for studying lipotropin function, melanocortin receptor interactions, and peptide stability. It is primarily utilized by pharmaceutical R&D teams, academic biochemistry laboratories, and biotechnology companies focused on metabolic and endocrine research. The product is supplied with a CAS Registry Number of 81483-91-2.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of β-lipotropin and its derived peptides like β-endorphin and melanocyte-stimulating hormones (MSH).
• Receptor Binding Assays: Essential for in vitro binding studies and functional characterization of melanocortin receptors (MCRs) due to its modified structure.
• Peptide Stability & Metabolism Studies: The acetyl group and D-amino acid substitution make it a valuable model for investigating peptide degradation pathways and metabolic stability.
• Pharmaceutical Development: Serves as a key intermediate or lead compound in the discovery of novel therapeutics targeting obesity, energy homeostasis, and skin pigmentation disorders.
• Analytical Standard: Employed in method development and calibration for analytical techniques such as HPLC and mass spectrometry in quality control laboratories.

Basic Information

Product Name	Acetyl-(D-Lys89,Sar90)-β-Lipotropin (88-91) (Human)
CAS No.	81483-91-2
Molecular Formula	C24H42N8O7
Molecular Weight	554.65 g/mol
Synonyms	Acetyl-β-Lipotropin (88-91), human; Acetyl-LPH (88-91); Acetyl-β-LPH (88-91); Ac-β-Lipotropin(88-91); Acetyl-(D-Lys89,Sar90)-β-Lipotropin (88-91); H-Ac-Tyr-Gly-Gly-Phe-NH2 (with D-Lys & Sar); Ac-Tyr-Gly-Gly-Phe-NH2 derivative; β-Lipotropin Fragment 88-91, Nα-acetyl-, (89-D-lysine,90-sarcosine)-
EINECS	Contact for details

Quality Control

Our Acetyl-(D-Lys89,Sar90)-β-Lipotropin (88-91) (Human) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development. Certificates of Analysis (COA) detailing purity by HPLC, peptide content, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.