Description

Caerulein, β-Asp(9)- is a synthetic analog of the natural decapeptide hormone caerulein, characterized by the substitution of an aspartic acid residue at position 9. This modification can influence its receptor binding affinity and metabolic stability, making it a valuable tool for biochemical and pharmacological research. It is primarily utilized in scientific studies investigating gastrointestinal physiology, pancreatic secretion, and cholecystokinin receptor signaling pathways. Researchers in pharmaceutical development and academic institutions rely on this high-purity peptide for consistent, reproducible experimental results.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of cholecystokinin (CCK) receptors and their downstream effects.
• Gastrointestinal Physiology Studies: Employed to stimulate pancreatic enzyme secretion and gallbladder contraction in experimental models.
• Neuroscience Research: Investigated for its potential neuromodulatory and anxiogenic effects in central nervous system studies.
• Biochemical Assay Development: Serves as a critical component in the development and validation of receptor binding assays and other in vitro test systems.
• Peptide Structure-Activity Relationship (SAR) Studies: The specific β-Asp(9) modification makes it a key compound for understanding how peptide sequence alterations affect biological activity.

Basic Information

Product Name	Caerulein, β-Asp(9)-
CAS No.	81456-41-9
Molecular Formula	C58H73N13O21S2
Molecular Weight	1352.4 g/mol
Synonyms	β-Asp(9)-Caerulein; Caerulein (9-aspartic acid); Asp(9)-Caerulein; Ceruletide (9-Asp analog); pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2; L-Aspartic acid, N-[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(5-oxo-L-prolyl)amino]-3-carboxy-1-oxopropyl]amino]-3-(4-hydroxyphenyl)-1-oxopropyl]amino]-3-hydroxy-1-oxopropyl]amino]-2-oxoethyl]amino]-3-(1H-indol-3-yl)-1-oxopropyl]amino]-3-(methylthio)-1-oxopropyl]amino]-3-carboxy-1-oxopropyl]amino]-1-oxo-3-phenylpropyl]-, (S)-; CCK-8 analog
EINECS	Contact for details

Quality Control

Our Caerulein, β-Asp(9)- is manufactured under strict quality systems to ensure the highest standards of purity and consistency for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity determination, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). A detailed Certificate of Analysis (COA) documenting the exact specifications, including purity (typically >95% by HPLC), is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	± 10% of theoretical
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.