Description

1-(3-Dimethylamino-1-Phenylpropyl)-4-(Ethoxycarbonyl)Piperazine Bis(Hydrogen Maleate) is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where consistent quality and reliable supply are paramount. It is primarily sought by research institutions and manufacturers in the global pharmaceutical and fine chemical sectors for the development and production of specialized therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular research.
• Active Pharmaceutical Ingredient (API) Development: Serves as a crucial precursor in the research, process development, and scale-up of new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct molecules with specific chiral centers, essential for producing enantiomerically pure compounds.
• Contract Manufacturing & Research (CMO/CRO): Supplied to contract organizations engaged in custom synthesis and process optimization for client projects.
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in regulatory filings.

Basic Information

Product Name	1-(3-Dimethylamino-1-Phenylpropyl)-4-(Ethoxycarbonyl)Piperazine Bis(Hydrogen Maleate)
CAS No.	81402-44-0
Molecular Formula	C22H33N3O8
Molecular Weight	467.52 g/mol
Synonyms	1-(3-Dimethylamino-1-phenylpropyl)-4-(ethoxycarbonyl)piperazine maleate (1:2); 4-(Ethoxycarbonyl)-1-[3-(dimethylamino)-1-phenylpropyl]piperazine dimaleate; (S)-1-(3-Dimethylamino-1-phenylpropyl)-4-(ethoxycarbonyl)piperazine bis(hydrogen maleate); Fencamfamin Impurity; Fencamfamin Related Compound; Piperazine, 1-[3-(dimethylamino)-1-phenylpropyl]-4-(ethoxycarbonyl)-, (2Z)-2-butenedioate (1:2); CAS 81402-44-0.
EINECS	Contact for details

Quality Control

Our production of 1-(3-Dimethylamino-1-Phenylpropyl)-4-(Ethoxycarbonyl)Piperazine Bis(Hydrogen Maleate) adheres to stringent quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical R&D and manufacturing. All materials are characterized and tested against comprehensive specifications using advanced analytical techniques (HPLC, GC, NMR, IR). A Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.