Description

Dl-Leucine (15N) is a stable isotope-labeled analog of the essential amino acid leucine, where the nitrogen atoms are enriched with the 15N isotope. This compound is a critical tool for advanced research in metabolism, protein synthesis, and nutrient tracing using techniques like mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers engaged in isotopic labeling studies and metabolic pathway analysis.

Application

• Metabolic Research & Tracer Studies: Used as a stable isotopic tracer to investigate amino acid metabolism, protein turnover, and metabolic fluxes in biological systems.
• Proteomics & Mass Spectrometry: Serves as an internal standard for the accurate quantification of leucine and related metabolites in complex biological samples via LC-MS/MS and GC-MS.
• NMR Spectroscopy: Provides a non-radioactive label for structural and dynamic studies of proteins, peptides, and metabolic products.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the incorporation of labeled amino acids into novel therapeutic compounds.
• Nutritional Science: Used in clinical and preclinical studies to assess protein synthesis rates, amino acid requirements, and metabolic responses to dietary interventions.
• Biochemical Manufacturing: Can be used in the synthesis of other 15N-labeled compounds, peptides, or complex biomolecules for research and diagnostic purposes.

Basic Information

Product Name	Dl-Leucine (15N)
CAS No.	81387-51-1
Molecular Formula	C6H13¹⁵NO2
Molecular Weight	132.18 g/mol (for ¹⁵N labeled)
Synonyms	(±)-Leucine-¹⁵N; DL-Leucine-¹⁵N; 2-Amino-4-methylpentanoic acid-¹⁵N; 15N Labeled DL-Leucine; Leucine (15N) racemic mixture; (RS)-2-Amino-4-methylpentanoic acid-¹⁵N; ¹⁵N-Leucine; UNII-61F81JE113 (component)
EINECS	Contact for details

Quality Control

Our Dl-Leucine (15N) is produced under controlled conditions to ensure high isotopic and chemical purity, meeting the stringent requirements of analytical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % ¹⁵N), chemical purity, and chiral purity. We adhere to cGMP principles for manufacturing, and our quality system ensures traceability and consistency for all research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Isotopic Enrichment (Atom % ¹⁵N)	≥ 98%
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Optical Purity (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.