Description

Somatostatin 28, Leu(8)-Trp(22)-Iodo-Tyr(25)- CAS NO 81381-96-6 is a synthetic, biologically active peptide analog of somatostatin, specifically engineered with modifications at positions 8, 22, and 25 to enhance its stability and receptor-binding affinity. This compound is critical for advanced research in endocrinology and neurobiology, serving as a potent tool for studying growth hormone and insulin regulation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic disorders and peptide-based therapeutic development.

Application

• Biomedical Research: Used as a high-affinity ligand in receptor binding assays and signal transduction studies related to somatostatin receptors (SSTRs).
• Pharmaceutical Development: Serves as a reference standard and a key intermediate in the research and development of novel peptide therapeutics targeting hormonal disorders.
• Metabolic Studies: Employed in in vitro and in vivo models to investigate the inhibition of growth hormone (GH), insulin, and glucagon secretion.
• Diagnostic Tool Development: Acts as a template for developing radiolabeled (e.g., with Iodine-125) probes for imaging and diagnostic applications in oncology and endocrinology.
• Academic & Clinical Research: Essential for fundamental research into the role of somatostatin in the central nervous system, gastrointestinal tract, and pancreatic function.

Basic Information

Product Name	Somatostatin 28, Leu(8)-Trp(22)-Iodo-Tyr(25)-
CAS No.	81381-96-6
Molecular Formula	C149H204N38O43SI
Molecular Weight	~3279.6 g/mol
Synonyms	Leu8,Trp22,Tyr25-I-somatostatin-28; [Leu8,Trp22,Tyr25-I]Somatostatin-28; Iodo-Tyr25-Somatostatin-28 analog; SRIF-28 (8-Leu, 22-Trp, 25-I-Tyr); Somatotropin Release-Inhibiting Factor analog; Ala-Gly-Cys-Lys-Asn-Phe-Phe-Leu-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bridge: Cys3-Cys14) with modifications; [Iodo-Tyrosine25]Somatostatin-28
EINECS	Contact for details

Quality Control

Every batch of Somatostatin 28, Leu(8)-Trp(22)-Iodo-Tyr(25)- is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and biological activity. Our quality commitment aligns with standards expected for research-grade peptides. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, amino acid analysis, and mass spectrometry (MS) data is provided with each shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere or with desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular ion peak consistent with theoretical mass
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	± 10% of theoretical composition
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.