Description

(D-Ala4)-Substance P (4-11) CAS NO 81381-50-2 is a synthetic peptide fragment and a potent, selective neurokinin-1 (NK1) receptor antagonist. This compound is a critical research tool for studying the physiological and pathological roles of Substance P, a key neuropeptide involved in pain transmission, neurogenic inflammation, and various central nervous system functions. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) engaged in neuroscience, pharmacology, and analgesic drug discovery programs.

Application

• Neuroscience Research: A fundamental tool for investigating the role of Substance P and NK1 receptors in pain pathways, migraine, anxiety, depression, and emesis.
• Pharmacological Assay Development: Used as a standard antagonist in receptor binding assays, functional cell-based assays, and high-throughput screening (HTS) to identify novel NK1 receptor modulators.
• Drug Discovery & Preclinical Studies: Serves as a reference compound for validating the efficacy and mechanism of action of new analgesic and neuropsychiatric drug candidates.
• Inflammation Research: Employed in studies of neurogenic inflammation, asthma, and inflammatory bowel disease where Substance P signaling is implicated.
• Academic & Institutional Research: Essential for university labs and research institutes conducting basic science on peptide signaling and receptor biology.

Basic Information

Product Name	(D-Ala4)-Substance P (4-11)
CAS No.	81381-50-2
Molecular Formula	C44H71N13O10S
Molecular Weight	950.2 g/mol
Synonyms	(D-Ala4)-Substance P (4-11); [D-Ala4]-Substance P (4-11); Substance P (4-11), [D-Ala4]-; [D-Ala4]-SP(4-11); Arg-Pro-Lys-Pro-D-Ala-Gln-Phe-Phe-Gly-Leu-Met-NH2; NK1 Receptor Antagonist (D-Ala4)-SP(4-11)
EINECS	Contact for details

Quality Control

Our (D-Ala4)-Substance P (4-11) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and mass spectrometry (MS) for identity confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.