Description

5-Chloro-2',3'-o-Isopropylidene-D-Uridine is a key protected nucleoside intermediate, specifically a halogenated derivative of uridine. This compound is critical for pharmaceutical research and development, enabling the precise synthesis of modified oligonucleotides and nucleoside analogs. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug discovery, oncology therapeutics, and probe development for molecular biology.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA strands for research, diagnostics, and therapeutic applications.
• Pro-drug Development: Serves as a protected precursor in the design of nucleoside-based pro-drugs to enhance bioavailability and targeting.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.
• Labeled Compound Synthesis: Acts as a starting material for introducing radioactive or fluorescent labels into nucleosides for tracking and imaging studies.
• Academic & Industrial R&D: Essential for chemical biology and medicinal chemistry programs in both university and corporate research laboratories.

Basic Information

Product Name	5-Chloro-2',3'-o-Isopropylidene-D-Uridine
CAS No.	81356-82-3
Molecular Formula	C12H15ClN2O6
Molecular Weight	318.71 g/mol
Synonyms	5-Chloro-2',3'-O-isopropylideneuridine; 5-Chloro-2',3'-O-(1-methylethylidene)uridine; 5-Chloro-2',3'-O-isopropylidene-D-uridine; 2',3'-O-Isopropylidene-5-chlorouridine; 5-Chloro-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione; 5-Chloro-2',3'-O-(1-methylethylidene)-D-uridine; D-Uridine, 5-chloro-2',3'-O-(1-methylethylidene)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2',3'-o-Isopropylidene-D-Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.