Description

Thyrotropin Releasing Hormone 5-Fluoroimidazole is a synthetic, fluorinated analog of the endogenous thyrotropin-releasing hormone (TRH), designed for advanced biochemical and pharmaceutical research. This modification enhances its metabolic stability and receptor interaction profile, making it a critical tool for studying neuroendocrine pathways and thyroid function. It is primarily utilized by research institutions and pharmaceutical developers focused on endocrinology, neuroscience, and novel peptide therapeutic discovery.

Application

• Neuroendocrine Research: As a potent TRH receptor agonist/antagonist tool compound for investigating the hypothalamic-pituitary-thyroid axis.
• Pharmacological Studies: Used in vitro and in vivo to study the effects of fluorinated peptides on receptor binding affinity, signal transduction, and metabolic stability.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the synthesis of related peptide analogs.
• Drug Discovery: A key intermediate or lead compound in the development of novel therapeutics for thyroid disorders and central nervous system diseases.
• Biochemical Assay Development: Employed in the development and validation of sensitive immunoassays or receptor-binding assays.

Basic Information

Product Name	Thyrotropin Releasing Hormone 5-Fluoroimidazole
CAS No.	81222-57-3
Molecular Formula	C16H22FN5O4
Molecular Weight	367.38 g/mol
Synonyms	5-Fluoroimidazole TRH; TRH 5-Fluoroimidazole analog; 5-Fluoro-His-Pro-NH2; L-Pyroglutamyl-5-fluoro-L-histidyl-L-prolinamide; 5-Fluoro-1H-imidazole-4-propanamide, 1-[(5-oxo-L-prolyl)-L-histidyl]-; 5-Fluoroimidazole Thyrotropin Releasing Hormone; 5-F-TRH; Fluorinated TRH Analog
EINECS	Contact for details

Quality Control

Our Thyrotropin Releasing Hormone 5-Fluoroimidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and specific tests for related substances and residual solvents, to ensure it meets the stringent requirements of research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under inert atmosphere (e.g., nitrogen or argon) after opening to minimize moisture absorption and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.