Description

Thyrotropin-Releasing Hormone, 2-Diazohistidinyl- is a chemically modified analog of the endogenous thyrotropin-releasing hormone (TRH). This specialized peptide is engineered for enhanced stability and targeted research applications, offering a valuable tool for probing neuroendocrine pathways. It is primarily utilized by research institutions and pharmaceutical development teams focused on endocrinology, neuroscience, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a stable, modified probe to study the structure-activity relationships (SAR) of the TRH receptor and its signaling mechanisms.
• Neuroendocrine Studies: Investigation of the hypothalamic-pituitary-thyroid (HPT) axis function and related feedback loops in experimental models.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the development of novel peptide analogs with potential diagnostic or therapeutic applications.
• In Vitro Diagnostics: Potential use in the development of specialized immunoassays or receptor-binding assays for research purposes.
• Metabolic Pathway Analysis: A tool for studying the role of TRH and its analogs in metabolic regulation and energy homeostasis.

Basic Information

Product Name	Thyrotropin-Releasing Hormone, 2-Diazohistidinyl-
CAS No.	81222-52-8
Molecular Formula	C16H22N8O4
Molecular Weight	390.40 g/mol
Synonyms	2-Diazo-His-TRH; 2-Diazohistidinyl-Thyrotropin Releasing Hormone; TRH, 2-Diazo-His-; L-Pyroglutamyl-L-2-diazohistidyl-L-prolinamide; (2-Diazo-L-histidyl)TRH; Pyroglutamyl-2-diazohistidyl-prolinamide; 2-Diazo-His-TRH Analog; TRH Analog, 2-Diazohistidinyl-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, identity, and impurity profiles. We adhere to Good Manufacturing Practice (GMP) principles for research-grade materials to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.