Description

Conotoxin Giv CAS NO 81133-24-6 is a highly specific and potent peptide neurotoxin derived from the venom of marine cone snails. This compound is of significant value in neuroscience research and drug discovery due to its selective antagonism of neuronal nicotinic acetylcholine receptors (nAChRs). It is an essential tool for researchers and pharmaceutical developers investigating pain pathways, neurological disorders, and novel therapeutic targets.

Application

• Neuroscience Research: As a selective antagonist for α3β2 and α6/α3β2β3 nAChR subtypes, it is a critical pharmacological tool for studying receptor function and signal transduction in the nervous system.
• Pain Pathway Analysis: Used in experimental models to investigate the role of specific nAChR subtypes in nociception and to validate novel targets for analgesic drug development.
• Drug Discovery & Development: Serves as a lead compound or a molecular template for designing new therapeutics targeting chronic pain, neuropathic conditions, and certain addiction disorders.
• Ion Channel Characterization: Employed in electrophysiology studies (e.g., patch-clamp) to characterize and block specific neuronal nicotinic acetylcholine channels with high precision.
• Biochemical Assays: Used in competitive binding assays and other in vitro tests to screen for new compounds interacting with the α3β2 nAChR subtype.
• Academic & Pharmaceutical R&D: A standard reagent in laboratories focused on neuropharmacology, toxicology, and the development of next-generation neuroactive pharmaceuticals.

Basic Information

Product Name	Conotoxin Giv
CAS No.	81133-24-6
Molecular Formula	C92H138N30O27S7
Molecular Weight	2288.7 g/mol
Synonyms	ω-Conotoxin GIV; Conotoxin GIV; ω-Conotoxin GIV; GIV Conotoxin; α-Conotoxin GIV; α-Conotoxin GIV; 81133-24-6; r11-Conotoxin Giv
EINECS	Contact for details

Quality Control

Our Conotoxin Giv is produced and handled under stringent quality protocols to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA), documenting purity, peptide content, and bioactivity data, is provided with every shipment to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. Aliquot into single-use vials to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single-Chain Proportion	≥ 90% (by HPLC)
Water Content (KF)	≤ 5.0%
Biological Activity	Verified by functional assay (e.g., nAChR inhibition)
Endotoxin Level	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.