Description

2-Methyl-D-Serine is a non-proteinogenic amino acid derivative characterized by a methyl group substitution on the alpha carbon of the D-serine backbone. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications requiring specific stereochemistry and molecular complexity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for neurologic and metabolic drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified serine residues, influencing peptide stability and bioactivity.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Agrochemical Development: Employed as a building block in the synthesis of advanced herbicides, pesticides, and plant growth regulators.
• Fine Chemical Production: Acts as a precursor for specialty chemicals, catalysts, and ligands used in asymmetric synthesis.

Basic Information

Product Name	2-Methyl-D-Serine
CAS No.	81132-44-7
Molecular Formula	C4H9NO3
Molecular Weight	119.12 g/mol
Synonyms	D-2-Methylserine; (R)-2-Amino-2-methyl-3-hydroxypropanoic acid; (R)-2-Methylserine; D-α-Methylserine; 2-Methyl-D-serine; (2R)-2-Amino-2-methyl-3-hydroxypropanoic acid; D-Threonine isomer
EINECS	Contact for details

Quality Control

Our 2-Methyl-D-Serine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with detailed results for parameters including assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.