Description

Racecadotril is a potent and selective enkephalinase inhibitor used as an antidiarrheal agent. Its primary value lies in its ability to reduce intestinal hypersecretion without affecting gastrointestinal motility, offering a targeted therapeutic approach. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for acute diarrhea and related gastrointestinal disorders. Racecadotril CAS NO 81110-73-8 is a key active pharmaceutical ingredient (API) in global healthcare.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription and over-the-counter antidiarrheal medications.
• Acute Diarrhea Treatment: Formulation into oral solid dosage forms (tablets, capsules) and oral suspensions for adults and pediatric patients.
• Gastrointestinal Research: A critical tool in pharmacological studies investigating intestinal secretion mechanisms and enkephalinase inhibition.
• Drug Development: Serves as a reference standard and a starting material for the synthesis of novel analogs and prodrugs.
• Veterinary Medicine: Potential application in formulations for treating diarrhea in companion and livestock animals.
• Combination Therapies: Used in conjunction with oral rehydration solutions (ORS) for comprehensive diarrhea management.

Basic Information

Product Name	Racecadotril
CAS No.	81110-73-8
Molecular Formula	C21H23NO4S
Molecular Weight	385.48 g/mol
Synonyms	Acetorphan; (3S)-3-[[(2S)-2-Acetyl-1-oxo-3-(phenylthio)propyl]amino]-2-oxo-5-phenylpentanoic acid benzyl ester; Tiorfan; RU-41705; Benzyl (3S)-3-[[(2S)-2-acetyl-1-oxo-3-(phenylsulfanyl)propyl]amino]-2-oxo-5-phenylpentanoate; N-[(R)-2-Acetylmercaptomethyl-1-oxo-3-phenylpropyl]glycine Benzyl Ester; Racecadotrilum
EINECS	Contact for details

Quality Control

Our Racecadotril is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines for active pharmaceutical ingredients. Each batch is subjected to comprehensive analytical testing including HPLC for assay and impurity profiling, residual solvent analysis, and specific tests for related substances. A Certificate of Analysis (COA) documenting purity, identity, and compliance with agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-25° to -30° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.