Description

Sennoside B CAS NO 128-57-4 is a bioactive anthraquinone glycoside primarily derived from plants of the *Cassia* genus. This compound serves as a critical active pharmaceutical ingredient (API) and reference standard due to its well-characterized pharmacological activity. It is essential for manufacturers and research institutions in the pharmaceutical, nutraceutical, and analytical chemistry sectors requiring high-purity botanical extracts for product development and quality control.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of stimulant laxatives and constipation relief medications.
• Reference Standard: Used in quality control laboratories for the identification and quantification of sennosides in raw materials and finished products via HPLC and TLC methods.
• Nutraceutical & Herbal Supplement: Key bioactive constituent in standardized herbal extracts for digestive health supplements.
• Research & Development: Vital compound for pharmacological studies investigating gastrointestinal motility, purgative mechanisms, and natural product chemistry.
• Cosmeceuticals: Investigated for potential use in topical formulations aimed at skin purification and detoxification claims.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for animal digestive health products.

Basic Information

Item	Details
Product Name	Sennoside B
CAS No.	128-57-4
Molecular Formula	C42H38O20
Molecular Weight	862.75 g/mol
Synonyms	Sennoside B; Sennoside B from Cassia angustifolia; Rhein-8-glucoside rhamnoside; 5,5'-Bis(β-D-glucopyranosyloxy)-9,9',10,10'-tetrahydro-4,4'-dihydroxy-10,10'-dioxo[9,9'-bianthracene]-2,2'-dicarboxylic acid dimethyl ester; Cassioside; (R)-Sennoside B; Senna extract constituent B
EINECS	204-897-5

Quality Control

Our Sennoside B is produced and tested under a strict quality management system. It can be supplied to meet various pharmacopoeial standards, including USP and EP monographs for Sennosides. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0% (on dried basis)
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.