Description

(2S)-2-Amino-3-[4-[2-Amino-6-[(1R)-1-[4-Chloro-2-(3-Methylpyrazol-1-Yl)Phenyl]-2,2,2-Trifluoroethoxy]Pyrimidin-4-Yl]Phenyl]Propanoic Acid, known as Telotristat, is a high-purity, non-systemic tryptophan hydroxylase inhibitor. This compound is critical for the development and production of targeted therapeutic agents, offering a specific mechanism of action for advanced pharmaceutical research. It serves as the active pharmaceutical ingredient (API) for the treatment of carcinoid syndrome diarrhea, making it essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on oncology and gastroenterology.

Application

• Active Pharmaceutical Ingredient (API): Primary use as the key therapeutic component in the formulation of Telotristat ethyl, the prodrug medication.
• Oncology & Gastroenterology Research: Critical for preclinical and clinical studies targeting serotonin-related pathologies, particularly carcinoid syndrome.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Development: Used in the development and optimization of scalable synthetic routes for commercial API manufacturing.
• Drug Discovery: A valuable tool compound for exploring new indications and combination therapies involving tryptophan hydroxylase inhibition.
• Regulatory Filings: Supplied as a characterized substance for inclusion in regulatory submission dossiers (e.g., DMF, CMC sections).

Basic Information

Product Name	(2S)-2-Amino-3-[4-[2-Amino-6-[(1R)-1-[4-Chloro-2-(3-Methylpyrazol-1-Yl)Phenyl]-2,2,2-Trifluoroethoxy]Pyrimidin-4-Yl]Phenyl]Propanoic Acid, Telotristat
CAS No.	1033805-28-5
Molecular Formula	C25H23ClF3N6O3
Molecular Weight	547.94 g/mol
Synonyms	Telotristat; Telotristat Free Base; Telotristat Impurity; LX-1032; (S)-2-Amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoic acid; UNII-6M1B29856N; 1033805-28-5
EINECS	Contact for details

Quality Control

Our Telotristat is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation, and controlled for specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support regulatory requirements and can supply material suitable for use under GMP guidelines for non-clinical and clinical stage development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. The original container should be kept tightly sealed in a desiccator when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Total)	≥99.0%
Single Unknown Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.