Description

Loperamide CAS NO 106900-12-3 is a synthetic opioid-receptor agonist specifically developed for its potent antidiarrheal properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical products. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of anti-diarrheal medications, both over-the-counter and prescription-based.

Application

• Primary API in the manufacture of anti-diarrheal tablets, capsules, and oral solutions.
• Key ingredient for pharmaceutical research and development of new gastrointestinal therapeutics.
• Used in the production of combination drug therapies targeting traveler's diarrhea and related conditions.
• Essential for generic drug manufacturers producing cost-effective alternatives to brand-name medications.
• Reference standard in analytical laboratories for quality control and method validation.
• Raw material for veterinary pharmaceutical applications under appropriate regulatory guidance.

Basic Information

Product Name	Loperamide
CAS No.	106900-12-3
Molecular Formula	C29H33ClN2O2
Molecular Weight	477.04 g/mol
Synonyms	Loperamide Hydrochloride; R-18553; Imodium; Loperamid; 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutyramide; (±)-Loperamide; Loperamidum; Loperamida
EINECS	Contact for details

Quality Control

Our Loperamide is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP, EP, and BP. Every batch undergoes comprehensive analytical testing including identification, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) confirming identity, purity, and conformance to agreed specifications is provided with each shipment to ensure regulatory compliance and supply chain integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.