Description

Dexecadotril CAS NO 112573-72-5 is a potent and selective enkephalinase inhibitor, functioning as a prodrug that is rapidly converted to its active metabolite. This compound is of significant interest in pharmaceutical research and development due to its mechanism of action, which modulates the endogenous enkephalin system. It is primarily utilized by pharmaceutical companies and research institutions engaged in the development of treatments for gastrointestinal disorders and pain management.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the formulation of prescription medications.
• Gastrointestinal Research: Key material for investigating and developing treatments for conditions like acute diarrhea and irritable bowel syndrome (IBS).
• Analgesic Drug Development: Used in research programs focused on novel pain relief mechanisms through enkephalinase inhibition.
• Biochemical Standard: Employed as a high-purity reference standard in analytical laboratories for quality control and method development.
• Preclinical & Clinical Studies: Essential for pharmacological testing, toxicology assessments, and clinical trial material manufacturing.
• Process Chemistry & Scale-Up: Used in the development and optimization of synthetic routes for commercial-scale API production.

Basic Information

Product Name	Dexecadotril
CAS No.	112573-72-5
Molecular Formula	C₂₁H₂₃NO₄S
Molecular Weight	385.48 g/mol
Synonyms	Racecadotril; (R)-Acetorphan; Tiorfan; RU-31158; N-[(R)-2-(Acetylthiomethyl)-1-oxo-3-phenylpropyl]glycine benzyl ester; (R)-[[2-(Acetylthiomethyl)-1-oxo-3-phenylpropyl]amino]acetic acid phenylmethyl ester; Benzyl N-[(2R)-2-(acetylthiomethyl)-3-phenylpropanoyl]glycinate
EINECS	Contact for details

Quality Control

Our Dexecadotril is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.