Description

2-Thioxo-3-(3-(Trifluoromethyl)Phenyl)-2,3-Dihydro-4(1H)-Quinazolinone is a specialized heterocyclic organic compound featuring a quinazolinone core substituted with a thioxo group and a 3-(trifluoromethyl)phenyl moiety. This molecular structure makes it a valuable advanced pharmaceutical intermediate and a key scaffold in medicinal chemistry research. It is primarily utilized by R&D organizations and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly for applications in oncology and targeted drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of potential drug candidates targeting specific enzymes or receptors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize biological activity and pharmacokinetic properties.
• Kinase Inhibitor Development: The quinazolinone structure is relevant for the research and development of small molecule kinase inhibitors.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of non-commercial, research-scale compounds.
• Academic Research: Used in university and institutional laboratories for exploratory synthetic chemistry and bioassay development projects.

Basic Information

Product Name	2-Thioxo-3-(3-(Trifluoromethyl)Phenyl)-2,3-Dihydro-4(1H)-Quinazolinone
CAS No.	81066-86-6
Molecular Formula	C15H9F3N2OS
Molecular Weight	322.31 g/mol
Synonyms	3-(3-(Trifluoromethyl)phenyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one; 2-Thioxo-3-[3-(trifluoromethyl)phenyl]-1,4-dihydro-2H-3,1-benzoxazin-4-one; 2-Thioxo-3-(3-trifluoromethylphenyl)-2,3-dihydro-4(1H)-quinazolinone; 4(1H)-Quinazolinone, 2,3-dihydro-2-thioxo-3-[3-(trifluoromethyl)phenyl]-; 81066-86-6
EINECS	Contact for details

Quality Control

Our 2-Thioxo-3-(3-(Trifluoromethyl)Phenyl)-2,3-Dihydro-4(1H)-Quinazolinone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.