Description

n-(γ-L-Glutamyl)-α-Naphthylamide Monohydrate is a specialized biochemical reagent used as a chromogenic substrate for enzymatic assays. Its value lies in its high specificity and sensitivity for detecting γ-glutamyl transpeptidase (GGT) activity, a critical diagnostic marker. This compound is essential for research institutions, clinical diagnostic laboratories, and pharmaceutical companies involved in liver function studies, cancer research, and the development of diagnostic kits.

Application

• Clinical Diagnostics: Primary substrate for the colorimetric and fluorometric determination of γ-Glutamyl Transpeptidase (GGT) activity in serum, a key biomarker for liver and biliary tract diseases.
• Biochemical Research: Used in enzyme kinetics studies to investigate the properties and inhibition of GGT, which is implicated in oxidative stress and tumor progression.
• Diagnostic Kit Manufacturing: A critical raw material in the production of commercial in-vitro diagnostic (IVD) test kits and reagents for automated clinical analyzers.
• Pharmaceutical Development: Employed in high-throughput screening (HTS) assays to identify and evaluate potential GGT inhibitor candidates for therapeutic applications.
• Cell Biology & Toxicology: Used to assay GGT activity in cell cultures and tissue samples to study cellular metabolism and the effects of hepatotoxic agents.

Basic Information

Product Name	n-(γ-L-Glutamyl)-α-Naphthylamide Monohydrate
CAS No.	81012-91-1
Molecular Formula	C₁₉H₂₁N₃O₅ • H₂O
Molecular Weight	383.40 g/mol (Monohydrate)
Synonyms	L-γ-Glutamyl-α-naphthylamide Monohydrate; γ-Glutamyl-α-Naphthylamide Monohydrate; GGT Substrate; α-Naphthylamide L-γ-Glutamyl Derivative; N-(L-γ-Glutamyl)-1-naphthylamine Monohydrate; 1-Naphthylamine, N-(L-γ-glutamyl)-, monohydrate; G-γ-GLN
EINECS	Contact for details

Quality Control

Our n-(γ-L-Glutamyl)-α-Naphthylamide Monohydrate is manufactured under strict quality systems suitable for diagnostic and research use. Each batch undergoes comprehensive analytical testing including HPLC for purity, identity confirmation by IR and NMR, and verification of substrate activity. Certificates of Analysis (COA) with detailed chromatograms and batch-specific data are provided to ensure traceability and performance consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. The product is hygroscopic and light-sensitive; prolonged exposure to moisture, heat, or light may affect stability and performance. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	4.0% - 6.0% (Theoretical for monohydrate: ~4.7%)
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents	Complies with ICH guidelines
Biological Activity	Suitable for GGT enzyme assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.