Description

H-Lys-Gly-Trp-Lys-Otbu CAS NO 80971-61-5 is a synthetic tetrapeptide derivative featuring a C-terminal tert-butyl ester (Otbu) protecting group. This compound is a crucial intermediate in peptide synthesis, offering controlled reactivity and solubility for advanced research and development. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions engaged in the discovery and development of novel peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the solid-phase and solution-phase synthesis of complex therapeutic peptides.
• Biochemical Research: Used in structure-activity relationship (SAR) studies to investigate the function of specific amino acid sequences.
• Protease Substrate Analog: Can be employed as a model substrate or inhibitor in enzymatic studies targeting trypsin-like proteases.
• Peptide Library Construction: A valuable component for generating focused peptide libraries for high-throughput screening in drug discovery.
• Conjugation Chemistry: The tert-butyl ester group allows for selective deprotection and subsequent conjugation to other molecules, carriers, or labels.

Basic Information

Product Name	H-Lys-Gly-Trp-Lys-Otbu
CAS No.	80971-61-5
Molecular Formula	C31H49N7O6
Molecular Weight	615.77 g/mol
Synonyms	Lys-Gly-Trp-Lys-Otbu; H-Lys-Gly-Trp-Lys-OtBu; Glycyl-L-tryptophyl-L-lysine tert-butyl ester; L-Lysyl-glycyl-L-tryptophyl-L-lysine 1,1-dimethylethyl ester; Tetrapeptide Lys-Gly-Trp-Lys-OtBu; Boc-Lys-Gly-Trp-Lys-Otbu (if N-terminal protected); 80971-61-5; tert-Butyl L-lysylglycyl-L-tryptophyl-L-lysinate
EINECS	Contact for details

Quality Control

Our H-Lys-Gly-Trp-Lys-Otbu is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the material meets your specific research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C. This product is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity	≥ 99.0% for each L-amino acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.