Description

Argipressin, 3-Mercapto-3-Methylbutyryl(1)-Metyr(2)- is a synthetic analogue of the neurohypophysial hormone arginine vasopressin, designed for enhanced stability and specific receptor binding. This compound is critical for research and development in advanced pharmaceutical applications, particularly where precise modulation of vasopressin pathways is required. It is primarily utilized by biopharmaceutical companies and research institutions focused on endocrinology, metabolic disorders, and novel peptide therapeutics.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of vasopressin receptor agonists and antagonists.
• Endocrinology Studies: For in vitro and in vivo research into the V1a and V2 receptor-mediated pathways, including studies on blood pressure regulation, renal function, and fluid balance.
• Metabolic Disorder Therapeutics: Investigation into potential treatments for conditions like diabetes insipidus and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
• Peptide Chemistry & Stability Research: Serving as a model compound for studying the effects of structural modifications (e.g., mercapto-methylbutyryl substitution) on peptide stability, bioavailability, and activity.
• Biochemical Assay Development: Used as a calibrated standard in competitive binding assays (ELISA, RIA) and functional cell-based assays to screen for new drug candidates.
• Preclinical Formulation: For the development of stable injectable or nasal spray formulations in preclinical animal studies.

Basic Information

Product Name	Argipressin, 3-Mercapto-3-Methylbutyryl(1)-Metyr(2)-
CAS No.	80953-31-7
Molecular Formula	C46H65N13O12S2
Molecular Weight	1040.2 g/mol
Synonyms	[Mpa1, Tyr(Me)2]-Arginine Vasopressin; [1-β-Mercapto-β,β-cyclopentamethylenepropionic acid, 2-O-methyltyrosine]-Arginine Vasopressin; d(CH2)5[Tyr(Me)2]AVP; SK&F 100398; V1a Vasopressin Receptor Antagonist; 3-Mercapto-3-methylbutyryl-1-O-methyltyrosine-2-Argipressin; Tyr(Me)-AVP; (1-β-Mercapto-β,β-cyclopentamethylenepropionic acid)-2-O-methyltyrosine-8-arginine vasopressin
EINECS	Contact for details

Quality Control

Our Argipressin, 3-Mercapto-3-Methylbutyryl(1)-Metyr(2)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, batch-to-batch consistency, and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0% (by weight)
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.