Description

Fibrinogen γ-Chain (397-411) is a synthetic peptide fragment corresponding to a specific sequence of the human fibrinogen gamma chain. This compound is a critical research tool for studying the molecular mechanisms of blood coagulation, platelet aggregation, and related thrombotic disorders. It is primarily utilized by researchers and developers in the fields of hemostasis, cardiovascular disease research, and diagnostic assay development.

Application

• Biochemical Research: Used as a specific substrate or inhibitor in studies of fibrinogen receptor (GP IIb/IIIa) interactions and platelet activation pathways.
• Anticoagulant/Thrombolytic Drug Development: Serves as a key reference standard and screening tool for developing novel therapeutic agents targeting fibrinogen binding sites.
• Diagnostic Reagent Production: Employed in the development and calibration of immunoassays and other diagnostic tests for coagulation disorders.
• Cell Adhesion Studies: Applied in vitro to investigate the role of fibrinogen fragments in cell-matrix interactions and inflammatory responses.
• Structure-Activity Relationship (SAR) Analysis: Used as a core sequence for synthesizing analogs to map critical binding epitopes on fibrinogen.

Basic Information

Product Name	Fibrinogen γ-Chain (397-411)
CAS No.	80755-86-8
Molecular Formula	C78H122N22O23S
Molecular Weight	1744.0 g/mol
Synonyms	Fibrinogen γ-chain (397-411); H-Gly-Pro-Arg-Val-Val-Gln-Pro-Arg-Val-Val-Glu-Arg-Pro-Pro-Cys-OH; Fibrinogen Gamma Chain Peptide (397-411); γ397-411 peptide; Fibrinogen receptor binding peptide; Platelet aggregation inhibitor peptide; GPRVVQPRVVERPPC; AGD peptide analog precursor
EINECS	Contact for details

Quality Control

Our Fibrinogen γ-Chain (397-411) is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and batch-to-batch consistency. Standard testing includes HPLC for purity, mass spectrometry (MS) for confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.