Description

1-Deamino-Triglycyl-8-Lysine-Vasopressin is a synthetic analogue of the neurohypophysial hormone vasopressin, specifically engineered for enhanced stability and research utility. This modified peptide is of significant interest due to its altered pharmacological profile, making it a valuable tool for investigating vasopressin receptor signaling pathways and related physiological processes. It is primarily utilized by pharmaceutical research organizations, academic institutions, and biotechnology companies engaged in advanced endocrinology, neuroscience, and peptide drug discovery programs.

Application

• Pharmacological Research: A key reference standard and active agent in studies of vasopressin (V1a, V1b, V2) receptor binding, activation, and downstream signaling cascades.
• Biochemical Assay Development: Used as a critical component in the development and validation of high-throughput screening (HTS) assays for drug discovery targeting vasopressin-related disorders.
• Structure-Activity Relationship (SAR) Studies: Serves as a core structural template for designing and evaluating new peptide analogues with modified potency, selectivity, or metabolic stability.
• Neuroscientific Investigations: Employed in experimental models to study the role of vasopressin in social behavior, memory, stress response, and autonomic regulation.
• Endocrine System Research: Utilized in vitro and in vivo to explore the modulation of water reabsorption, blood pressure, and corticosteroid release.
• Quality Control & Method Validation: Acts as a certified reference material (CRM) for analytical method development and quality control in peptide synthesis and characterization laboratories.

Basic Information

Product Name	1-Deamino-Triglycyl-8-Lysine-Vasopressin
CAS No.	80741-20-4
Molecular Formula	C52H78N16O15S2
Molecular Weight	1199.4 g/mol
Synonyms	dTG-LVP; 1-Deamino-8-Lysine-Vasopressin Triglycyl Derivative; Desmopressin Triglycyl Lysine Analogue; [1-β-Mercaptopropionic acid, 8-Lysine]vasopressin triglycyl amide; TG-LVP; Glycyl-Glycyl-Glycyl-1-Deamino-8-Lysine-Vasopressin; Vasopressin, 1-deamino-8-lysine-, triglycyl-; (1-β-Mercaptopropionic acid, 8-L-lysine)vasopressin triglycyl amide
EINECS	Contact for details

Quality Control

Our 1-Deamino-Triglycyl-8-Lysine-Vasopressin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) detailing all critical quality attributes, ensuring the material meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by AAA)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.