Description

Dansyl-Glycyl-Nitrophenylalanyl-Proline CAS NO 80733-88-6 is a specialized, high-purity synthetic peptide derivative designed for advanced research and development applications. This compound serves as a critical biochemical tool, valued for its unique chromophoric and fluorogenic properties that enable sensitive detection and analysis. It is primarily utilized by pharmaceutical researchers, diagnostic kit developers, and academic institutions engaged in protease activity studies, enzyme kinetics, and fluorescence-based assay development.

Application

• Protease Substrate & Enzyme Assay Development: Acts as a specific, sensitive fluorogenic substrate for studying the activity and inhibition of various proteolytic enzymes.
• Biochemical Research & Mechanism Studies: Used in fundamental research to investigate enzyme kinetics, catalytic mechanisms, and protein-protein interactions.
• Diagnostic Reagent Manufacturing: Serves as a key component in the formulation of high-sensitivity diagnostic kits for clinical and research laboratories.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors as potential drug candidates.
• Peptide Chemistry & Conjugation Studies: Utilized as a model compound or a building block in advanced peptide synthesis and conjugation chemistry due to its dansyl and nitrophenyl functional groups.

Basic Information

Product Name	Dansyl-Glycyl-Nitrophenylalanyl-Proline
CAS No.	80733-88-6
Molecular Formula	C30H34N6O8S
Molecular Weight	638.70 g/mol
Synonyms	Dansyl-Gly-pNA-Pro; Dns-Gly-pNA-Pro; 5-(Dimethylamino)naphthalene-1-sulfonyl-glycyl-4-nitrophenylalanyl-proline; Glycine, N-[N-[N-[(5-dimethylamino-1-naphthalenyl)sulfonyl]glycyl]-3-(4-nitrophenyl)-L-alanyl]-, L-prolyl; Fluorogenic Protease Substrate; Peptide Protease Substrate 80733-88-6
EINECS	Contact for details

Quality Control

Every batch of Dansyl-Glycyl-Nitrophenylalanyl-Proline is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and performance consistency. Our quality assurance protocol includes advanced chromatographic and spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 98.0% (on dried basis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.