Description

3',4'-Dideoxyparomomycin is a semi-synthetic derivative of the aminoglycoside antibiotic paromomycin, specifically modified to explore structure-activity relationships and enhance specific biological properties. This compound is of significant interest in pharmaceutical research for the development of novel antimicrobial agents and as a critical biochemical tool. It is primarily utilized by research institutions and pharmaceutical companies engaged in antibiotic discovery, microbiological studies, and the synthesis of advanced therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and development of next-generation aminoglycoside antibiotics.
• Biochemical Research: Used as a reference standard and probe in studies investigating bacterial ribosome function and antibiotic resistance mechanisms.
• Microbiology Studies: Employed in in vitro assays to evaluate antimicrobial activity against a spectrum of bacterial strains.
• Structure-Activity Relationship (SAR) Analysis: Critical for medicinal chemistry programs aiming to optimize the efficacy and reduce the toxicity of aminoglycoside derivatives.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and medicinal chemistry.

Basic Information

Product Name	3',4'-Dideoxyparomomycin
CAS No.	80451-74-7
Molecular Formula	C23H45N5O12
Molecular Weight	583.63 g/mol
Synonyms	3',4'-Dideoxyparomamine; Paromomycin 3',4'-dideoxy derivative; 4-O-(2,6-Diamino-2,6-dideoxy-α-L-glucopyranosyl)-2-deoxy-D-streptamine 6-O-β-D-ribofuranoside derivative; Antibiotic U-58820; (2R,3S,4R,5R,6S)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-3,5-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
EINECS	Contact for details

Quality Control

Our 3',4'-Dideoxyparomomycin is produced under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.