Description

Ulinastatin CAS NO 80449-31-6 is a potent glycoprotein trypsin inhibitor derived from human urine, widely recognized for its anti-inflammatory and cytoprotective properties. This compound is critical for modulating proteolytic enzyme activity and stabilizing cellular membranes under stress conditions. It is an essential active pharmaceutical ingredient (API) and research biochemical for the pharmaceutical, biotechnology, and life science research sectors, particularly in developing treatments for pancreatitis, septic shock, and ischemia-reperfusion injury.

Application

• Pharmaceutical API: Primary active ingredient in injectable formulations for the treatment of acute pancreatitis and circulatory shock.
• Critical Care Medicine: Used in therapies for sepsis, systemic inflammatory response syndrome (SIRS), and multiple organ dysfunction syndrome (MODS).
• Surgical Adjunct: Administered to mitigate ischemia-reperfusion injury associated with major surgeries, including cardiopulmonary bypass and organ transplantation.
• Biochemical Research: Vital tool for studying protease inhibition pathways, inflammatory cascades, and cellular apoptosis in laboratory settings.
• Diagnostic Reagent Component: Employed in the development of enzyme-linked immunosorbent assay (ELISA) kits and other diagnostic assays.
• Stem Cell & Tissue Culture: Used in media supplements to protect cells from trypsin-induced damage during subculturing processes.

Basic Information

Product Name	Ulinastatin
CAS No.	80449-31-6
Molecular Formula	C20H32N4O5S2
Molecular Weight	496.62 g/mol
Synonyms	Urinary Trypsin Inhibitor (UTI); Miraclid; UTI; Bikunin; HI-30; Urinastatin; Inter-α-trypsin inhibitor light chain; IαI
EINECS	Contact for details

Quality Control

Our Ulinastatin is manufactured under strict cGMP guidelines to ensure the highest standards of purity and biological activity. Each batch is subjected to a comprehensive battery of tests including HPLC for purity, peptide mapping, bioactivity assays, and stringent endotoxin testing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Specific Activity	≥ 50,000 U/mg protein
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.